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Control based on on-line optimization, popularly known as model predictive control (MPC), has long been recognized as the winning alternative for constrained systems. The main limitation of MPC is, however, its on-line computational complexity. For discrete-time linear time-invariant systems with constraints on inputs and states, we develop an algorithm to determine explicitly the state feedback control law associated with MPC, and show that it is piecewise linear and continuous. The controller inherits all the stability and performance properties of MPC, but the online computation is reduced to a simple linear function evaluation instead of the expensive quadratic program. The new technique is expected to enlarge the scope of applicability of MPC to small-size/fast-sampling applications which cannot be covered satisfactorily with anti-windup schemes.

An advanced model-based control technique for regulating the blood glucose for patients with Type 1 diabetes is presented. The optimal insulin delivery rate is obtained off-line as an explicit function of the current blood glucose concentration of the patient by using novel parametric programming algorithms, developed at Imperial College London. The implementation of the optimal insulin delivery rate, therefore, requires simple function evaluation and minimal on-line computations. The proposed framework also addresses the uncertainty in the model due to interpatient and intrapatient variability by identifying the model parameters which ensure that a feasible control law can be obtained. The developments reported in this paper are expected to simplify the insulin delivery mechanism, thereby enhancing the quality of life of the patient.

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