(1) The variation in cytologic diagnoses within benign pathologies can be attributed to the coexistence of nonuniform pathologies. Aspirations performed in different sites of the nodule would contribute to obtain a more representative specimen. (2) In the absence of suspicious clinical changes and with at least three FNAs confirming the cytologic diagnosis of benignity, the follow-up of nodules by FNA could be discontinued and (3) In our experience, the diagnostic change from benign to malignant after three repeat FNAs appears to indicate that it would be advisable to perform three procedures.
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