A new stereoisomer Meso-araguspongine C together with nine reported macrocyclic bis-quinolizidine alkaloids araguspongines A, C, E, L, N-P, petrosin, and petrosin A were isolated from marine sponge Xestospongia muta. Stereochemistry of meso-araguspongine C (2) and araguspongines N-P (3-5) were established by their NMR data and conformational analyses. Both araguspongine C (1) and meso-araguspongine C (2) exhibited great cytotoxic activity towards HepG-2, HL-60, LU-1, MCF-7, and SK-Mel-2 human cancer cells (IC in the range of 0.43-1.02 μM). At a concentration of 20 μM, isolated compounds (1-10) also showed modest inhibitory effects (from 7.6 to 40.8%) on the NO production in LPS activated RAW264.7 macrophages.
Four new cucurbitane- type triterpene glycosides, charantosides D-G (1–4) were isolated from a methanol extract of Momordica charantia fruits. The structures of these compounds were determined by chemical and spectroscopic methods to be (19 R)-5 β,19-epoxy-25-methoxycucurbita-6,23-diene-3 β,19-diol 3- O-β-D-glucopyranoside, (19 R)-5 β,19-epoxy-25-methoxycucurbita-6,23-diene-3 β,19-diol 3- O-β-D-allopyranoside, 7 β-methoxycucurbita-5,23 E,25-triene-3 β-ol 3- O-β-D-allopyranoside, and 3 β,7 β-dihydroxycucurbita-5,23 E,25-triene-19-al 3- O-β-D-allopyranoside.
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