Background
Gastric cancer (GC) is one of the leading causes of morbidity and mortality worldwide. The onset and progression of gastric cancer are attributed to numerous triggers, these triggers may be infection of the gastric epithelium by
Helicobacter pylori
(
H. pylori
), or by Epstein-Barr virus (EBV). Both agents can establish a lifelong persistent infection in the host, leading to chronic inflammation, which also contributes to cancer development. Objective: The objective of this study is to present the status of co-infection with
H. pylori
and EBV and the risk of developing adenocarcinoma at an early age in the population of Grand Casablanca.
Methods
In this study, 100 gastric tissue samples from patients with gastric cancer were examined for detection of
H. pylori
and EBV in tumor tissue using PCR techniques, and the clinical relevance was statistically analyzed.
Results
Results revealed an individual Epstein-Barr virus (EBV) infection observed in (40 %) of gastric carcinoma cases. Furthermore, the frequency of EBV infection was significantly different with intestinal and diffuse gastric cancer types [15 % vs. 85 %; <0.05]. The prevalence of individual
H. pylori
infections was 34 %, while the frequency of co-infection was 16 %. Moreover, no significant association was found between co-infection and sex, tumor grade, stage, and lymph node metastasis, but there was a significant association between co-infection and the age of GC patients.
Conclusion
Thus understanding the status of co-infection could clarify the process of gastric carcinogenesis, and application of this knowledge for clinical purposes could facilitate diagnosis, risk management, and prevention.
Le textilome, également appelé gossybipomas, est une complication postopératoire très rare. Il peut s'agir d'un corps étranger composé de compresse(s) ou champ(s) chirurgicaux oubliés au niveau d'un foyer opératoire. Ils sont plus souvent asymptomatiques, et difficile à diagnostiquer. En particulier, les cas chroniques ne présentent pas de signes cliniques et radiologiques spécifiques pour le diagnostic différentiel. L'anamnèse est donc indispensable pour le diagnostic vu que les signes cliniques ne sont pas concluants. Le cliché d'abdomen sans préparation est peu contributif, l’échographie est fiable. La tomodensitométrie permet un diagnostic topographique précis, mais ce n'est pas toujours le cas. Certaines équipes proposent des explorations par IRM. Nous rapportons un cas de textilome intra abdominal, chez une patiente de 31 ans opérée il y a 8 ans pour grossesse extra-utérine, chez qui la TDM abdomino-pelvienne a évoqué un kyste hydatique péritonéale sans localisation du foie. Traitée par extrait d'un petit champ de 25x15cm et adhérant au sigmoïde. Le but de ce travail est de mettre en évidence le problème de diagnostic de cette pathologie et l'importance de la laparotomie exploratrice.
Background
Venous thrombosis has been described as a common complication for cancer patients. The association between clotting factor gene polymorphisms and the risk of colorectal cancer has been evidenced. The aim of the present study was to investigate the association of G20210A factor II prothrombin (FII) and factor V Leiden ( FVL) G1691A with the risk of colorectal cancer(CRC).
Methods and results
Genotyping of FVL and G20210A FII was performed using the polymerase chain reaction restriction fragment length polymorphism method on a sample of 76 patients with CRC as well as 182 controls. No significant difference in FVL gene variations was observed between cases and controls. However, with regard to the G20210A FII, the homozygous mutated genotype AA was associated with an increased risk of CRC. A significant association between the G20210A FII mutation and the risk of CRC was identified using recessive (OR=57.63, 95% CI: 3.33–997.26, P=0.0053), dominant (OR=27.87, 95% CI: 12.67 −61.28, P<0, 0001) and additive (OR=21.24, 95% CI: 10.45–43.16, P<0, 0001) models. No statistical difference was observed in parameters such as sex, age and positive family history for cancer.
Conclusion
Our results did not support an effect of FVL gene on CRC risk and suggested that the G20210A FII prothrombin gene variant may be a risk factor for CRC in Moroccan population.
Altogether these findings suggest that EG-VEGF/receptors system might be an important actor in the CRC progression into PC and might be involved in the ability of tumor cells to invade other organs. Circulating EG-VEGF could be proposed as a prognostic marker in human CRC and its progression into PC.
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