In this population-based study, CD and UC incidences increased dramatically in adolescents across a 24-year span, suggesting that one or more strong environmental factors may predispose this population to IBD.
The negative resection margin represents the most important prognostic factor. Adjuvant gemcitabine-based chemotherapy appears to benefit survival. The neutrophil-to-lymphocyte ratio may potentially be used to stratify patients for future clinical trials.
Extraintestinal manifestations occurred at lower frequency in elderly-onset compared with pediatric-onset patients. In both age populations, presence of EIM at diagnosis independently increased the need for corticosteroid and immunosuppressive treatment.
RezumatLimfomul difuz cu celulă mare B mamar la bărbaţi reprezintă o entitate rară ce poate mima carcinomul mamar ca prezentare clinică, de aceea tratamentul iniţial pentru majoritatea pacienţilor rămâne cel chirurgical. Diagnosticul şi tratamentul precoce complementar, chimioterapia şi radioterapia, sunt foarte importante. Vom prezenta cazul unui bărbat de 56 ani diagnosticat cu limfom difuz cu celulă mare B, primitiv cu localizare mamară -formaţiune tumorală mamară fără limfadenopatie axilară. În urma biopsiei mamare, examenul histopatologic susţinut de testele imunohistochimice stabilesc diagnosticul de limfom difuz cu celula mare B mare primitiv cu pozitivitate pentru CD 20, CD 10, şi negativitate pentru BCL 2, myc şi BCL 6 cu index de proliferare foarte mare (Ki 67 90%). Pacientul a primit trei cure de chimioterapie R-CHOP (rituximab, ciclofosfamida, adriamicina, vincristine si prednisolon). Limfomul difuz cu celulă mare primitiv mamar la bărbat reprezintă o entitate foarte rară, fiind necesară o supiciune ridicată pentru diagnosticul şi tratamentul precoce.Cuvinte cheie: limfom difuz cu celule mare B, sân, bărbat, tratament
Background and aims:Patients now want a long-lasting youthful appearance but with a minimally-invasive approach. Our unique approach, "AdipoLASER reJuvenation (ALJ)", involves a variety of minimally-invasive laser-and lipolysis-based techniques, and the present study assessed the impact of this ALJ approach. Subjects and Methods: From 2008 -2011, we prospectively enrolled 221 patients into the study. 71 of them, underwent the ALJ approach: 2 reductive techniques via microliposuction and laserassisted lipolysis (LAL); and 2 regenerative techniques via autologous fat graft and fractional CO2 laser resurfacing. The remaining 150 patients underwent only 1 or 2 of these techniques. Patients were monitored through 1 to 18 months, clinical photography was taken and histological assessments were performed. Results: ignificantly better and long-lasting results were obtained for the complete ALJ approach regarding all aspects of the face, mandible and neck compared with controls. The combination of the regenerative and the reductive approaches delivered on excellent balance, restoring a youthful, natural appearance to the face. Conclusions: The fractional CO2 laser has both a photodestructive, or HLLT, effect and an LLLT component in the beam periphery. This LLLT effect possibly prolonged the life and improved the take of the fat grafts, with the well-documented HLLT effect inducing swift collagenesis and better remodeling of the dermal matrix. A natural look in depressed areas was thus restored with the combination of fat redistribution and the HLLT/LLLT effect. Microlipolysis and laser-assisted lipolysis (LAL) could at the same time remove those areas of redundant and prolapsed fat while countering skin laxity, and address both jowl formation and submental flaccidity. The unique combination of all four approaches in our "AdipoLASER reJuvenation" proved to be superior to any other lesser approach in both the long-and short term with very little patient downtime, but did not present much more in terms of treatment time and cost to the patient. We believe that the ALJ approach offers a real minimally-invasive alternative to the classic surgical facelift
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