The purpose of this study was to develop monodispersed polystyrene particles as certified reference materials in accordance with the ISO 17034: 2016 and the ISO Guide 35. It can play a significant role especially during the COVID-19 pandemic since several covering items such as filtering facepiece respirators or medical masks must be investigated for the quality of operation by various sizes of polystyrene. The polystyrene particles were prepared in-house by National Nanotechnology Center (NANOTEC) using polymerization of styrene. Each batch was preliminary check for distribution, aggregation and averaged size by using dynamic light scattering. Then polystyrene particles were prepared to 1% solid suspension in deionized water for homogeneity testing, stability assessment and characterization using transmission electron microscope with ImageJ software. The 100 nm polystyrene as an example has been successfully synthesized fulfilled the criteria of size deviation from nominal value less than ± 10 nm and polydispersity index less than 0.05. Then, the particle size of polystyrene was statistically analyzed for screening test with the results of the coefficient of variation less than 10%. Stability assessment consisting of short-term stability testing with three different temperatures and long-term stability testing within 6 months observed was carried out. The results of short-term and long-term stability were presented within the maximum acceptable. The homogeneity tests for within bottle standard deviation and between bottle standard deviation were performed with randomly sampling. The results of homogeneity tests satisfied the criteria and therefore assigned the value as the certify value. Consequently, the certify value of 105.5 ± 4.6 nm of monodispersed polystyrene particles has been successfully developed as Thailand reference materials which were similar level of quality and accuracy to the standard commercial products.
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