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Background. Medicinal plants have proved at all times to be a powerful remedy for health care. Accordingly, grape seed, sesame, and fenugreek extracted oils with pharmacological properties are investigated as wound treatments. This study assesses the potential of our oils for healing wounds induced on rats. Methods. Phytochemical analyses of oils have involved: quality value, polyphenol, chlorophylls, carotene, and fatty acids. Antibacterial activity was carried out. Antioxidant activity was evaluated: the scavenging effect on DPPH radicals, the reducing power, and β-carotene discoloration. Uniform wound excision was induced on rats dorsum randomly divided into five groups: groups treated with “CICAFLORA®” and tested oils and untreated one. The posthealing biopsies were histologically assessed. Results. Wound biopsies treated with oils showed the best tissue regeneration compared to control groups. Groups treated with our oils and “CICAFLORA” had higher wound contraction percentage. Polyunsaturated fatty acids in oils act as inflammatory mediators increasing neovascularization, extracellular remodeling, migration, and cell differentiation. Wound healing effect was attributed to antibacterial and antioxidant synergy. Conclusion. According to findings, oils showed better activity in wound healing compared to “CICAFLORA” due to a phytoconstituents synergy. However, clinical trials on humans are necessary to confirm efficacy on human pathology.

<b><i>Background:</i></b> <i>Lawsonia inermis</i>-extracted oil is known for therapeutic properties, especially wound healing. This study assesses the potential of this oil for wound healing in a rat model. <b><i>Methodology:</i></b> To assess the potential of <i>L. inermis-</i>extracted oil for wound healing, phytochemical, antibacterial, and antioxidant analyses were conducted. Uniform wound excision was induced on the dorsum of randomly selected rats divided into 3 groups cleaned and treated with saline solution (control), Cicaflora (reference), and <i>L. inermis</i>oil. Biopsies performed after healing were histologically assessed. <b><i>Conclusions:</i></b> The quality and content of the fatty acids in the oil were determined. Results showed a high content of bioactive components inducing an efficient wound healing effect determined by an in vivo study. Histological and chromatic assessment findings revealed healing in the oil-treated group but not in the untreated group, a full reepithelialization with reappearance of skin appendages and well-organized collagen fibers without any inflammatory cells. This might be due to a synergistic effect of the phytoconstituents present in the oil.

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Heliotropium europaeum has been traditionally used to stop bleeding and accelerate scarring. This study provides a scientific evaluation of Heliotropium europaeum's hemostatic and healing potential. To evaluate the haemostatic effect of Heliotropium europaeum, the time of bleeding of fresh wounds induced experimentally in rats was studied. Excision wounds were induced upon four groups; each one contains six rats to estimate the healing properties of wounds. Group-1 was assigned as control (not treated), group-2 was daily treated with Heliotropium europaeum leaf powder, group-3 was treated with Heliotropium europaeum every 6 days and group-4 was treated with a reference drug, an emulsion containing 10% of Mimosa tenuiflora extract. All the parameters were significantly tested (P < 0.05) with comparison to a group control. The use of Heliotropium europaeum significantly shortened the bleeding time. The rats which were daily treated with Heliotropium europaeum healed in 12 days. This time period was significantly shorter than the control groups. Wound excision was uniformly induced randomly on the dorsum of rats in 4 groups (tested support and control). The post healing biopsies were histologically assessed, revealed a better healing quality, and continue complete tissue regeneration, abundant and well organized network of collagen fibers, and low numbers of inflammatory cells. The experimental data revealed that Heliotropium europaeum displayed remarkable haemostatic and wound healing activities.