The outbreak of COVID-19 has led to a global effort to decelerate the pandemic spread. For this purpose chest computed-tomography (CT) based screening and diagnosis of COVID-19 suspected patients is utilized, either as a support or replacement to reverse transcription-polymerase chain reaction (RT-PCR) test. In this paper, we propose a fully automated AI based system that takes as input chest CT scans and triages COVID-19 cases. More specifically, we produce multiple descriptive features, including lung and infections statistics, texture, shape and location, to train a machine learning based classifier that distinguishes between COVID-19 and other lung abnormalities (including community acquired pneumonia). We evaluated our system on a dataset of 2191 CT cases and demonstrated a robust solution with 90.8% sensitivity at 85.4% specificity with 94.0% ROC-AUC. In addition, we present an elaborated feature analysis and ablation study to explore the importance of each feature.
Purpose: Cerebrovascular vessel segmentation is a key step in the detection of vessel pathology. Brain time-of-flight magnetic resonance angiography (TOF-MRA) is a main method used clinically for imaging of blood vessels using magnetic resonance imaging. This method is primarily used to detect narrowing, blockage of the arteries, and aneurysms. Despite its importance, TOF-MRA interpretation relies mostly on visual, subjective assessment performed by a neuroradiologist and is mostly based on maximum intensity projections reconstruction of the threedimensional (3D) scan, thus reducing the acquired spatial resolution. Works tackling the central problem of automatically segmenting brain blood vessels typically suffer from memory and imbalance related issues. To address these issues, the spatial context of the segmentation consider by neural networks is typically restricted (e.g., by resolution reduction or analysis of environments of lower dimensions). Although efficient, such solutions hinder the ability of the neural networks to understand the complex 3D structures typical of the cerebrovascular system and to leverage this understanding for decision making.Approach: We propose a brain-vessels generative-adversarial-network (BV-GAN) segmentation model, that better considers connectivity and structural integrity, using prior based attention and adversarial learning techniques.Results: For evaluations, fivefold cross-validation experiments were performed on two datasets. BV-GAN demonstrates consistent improvement of up to 10% in vessel Dice score with each additive designed component to the baseline state-of-the-art models.Conclusions: Potentially, this automated 3D-approach could shorten analysis time, allow for quantitative characterization of vascular structures, and reduce the need to decrease resolution, overall improving diagnosis cerebrovascular vessel disorders.
The outbreak of COVID-19 has lead to a global effort to decelerate the pandemic spread. For this purpose chest computed-tomography (CT) based screening and diagnosis of COVID-19 suspected patients is utilized, either as a support or replacement to reverse transcription-polymerase chain reaction (RT-PCR) test. In this paper, we propose a fully automated AI based system that takes as input chest CT scans and triages COVID-19 cases. More specifically, we produce multiple descriptive features, including lung and infections statistics, texture, shape and location, to train a machine learning based classifier that distinguishes between COVID-19 and other lung abnormalities (including community acquired pneumonia). We evaluated our system on a dataset of 2191 CT cases and demonstrated a robust solution with 90.8% sensitivity at 85.4% specificity with 94.0% ROC-AUC. In addition, we present an elaborated feature analysis and ablation study to explore the importance of each feature.
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