1. Thrombi were produced in the marginal vein of the ear of rabbits with the use of either thrombin or sodium morrhuate. Sodium morrhuate was found to be most dependable.
2. Plasmin given intravenously with an average dose of 10 to 15 ml. per Kg. was effective in producing a complete intravascular lysis in all instances where the thrombus was less than 24 hours old, and a partial or total lysis in the great majority of animals with thrombi over 24 hours old. This lysis took place within 1 to 2 hours after the injection of plasmin.
3. The intravenous use of plasmin is shown in rabbits to be nonlethal and nontoxic.
1. The fibrinolytic and proteolytic activity of serum plasminogen, activated by Streptokinase and Staphylokinase and measured by clot lysis and casein digestion, was studied in the following species of animals: human, cow, dog, horse, monkey, pig, rabbit, rat, and chicken.
2. A significant difference in fibrinolytic and proteolytic activity of serum plasminogen (activated by staphylokinase) was observed in three animal species: monkey, horse, and human. The significance of this observation is briefly discussed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.