Malignant skin tumors of different types were studied in vivo using optical coherence tomography (OCT), backscattering (BS), and Raman spectroscopy (RS). A multimodal method is proposed for early cancer detection based on complex analysis of OCT images by their relative alteration of scattered-radiation spectral intensities between malignant and healthy tissues. An increase in average accuracy of diagnosis was observed for a variety of cancer types (9% sensitivity, 8% specificity) by a multimodal RS-BS-OCT system in comparison with any of the three methods used separately. The proposed approach equalizes the processing rates for all methods and allows for simultaneous imaging and classification of tumors.
Optical coherence tomography (OCT) is employed in the diagnosis of skin cancer. Particularly, quantitative image features extracted from OCT images might be used as indicators to classify the skin tumors. In the present paper, we investigated intensity-based, texture-based and fractalbased features for automatically classifying the melanomas, basal cell carcinomas and pigment nevi. Generalized estimating equations were used to test for di®erences between the skin tumors. A modi¯ed p value of < 0.001 was considered statistically signi¯cant. Signi¯cant increase of mean and median of intensity and signi¯cant decrease of mean and median of absolute gradient were observed in basal cell carcinomas and pigment nevi as compared with melanomas. Signi¯cant decrease of contrast, entropy and fractal dimension was also observed in basal cell carcinomas and pigment nevi as compared with melanomas. Our results suggest that the selected quantitative image features of OCT images could provide useful information to di®erentiate basal cell carcinomas and pigment nevi from the melanomas. Further research is warranted to determine how this approach may be used to improve the classi¯cation of skin tumors.
In this paper, the new method for OCT images denoizing based on empirical mode decomposition (EMD) is proposed. The noise reduction is a very important process for following operations to analyze and recognition of tissue structure. Our method does not require any additional operations and hardware modi¯cations. The basics of proposed method is described. Quality improvement of noise suppression on example of edge-detection procedure using the classical Canny's algorithm without any additional pre-and post-processing operations is demonstrated. Improvement of rawsegmentation in the automatic diagnostic process between a tissue and a mesh implant is shown.
Abstract. In the ophthalmic research, the measurement of the retinal thickness is usually employed for characterizing the structural changes of the retinal tissue. However, changes in the fractal dimension (FD) may provide additional information regarding the structure of the retinal layers and their early damage in ocular diseases. In the present paper, we investigated the possibility of detecting changes in the structure of the cellular layers of the retina by applying a two-dimensional fractal analysis to optical coherence tomography (OCT) images. OCT images were obtained from diabetic patients without retinopathy (DM, n = 38 eyes) and with mild diabetic retinopathy (MDR, n = 43 eyes) as well as in healthy subjects (Controls, n = 74 eyes). The two-dimensional fractal dimension was calculated using the differentiate box counting methodology. We evaluated the usefulness of quantifying the fractal dimension of layered structures in the detection of retinal damage. Generalized estimating equations considering within-subject inter-eye relations were used to test for differences between the groups. An adjusted p-value of <0.001 was considered statistically significant. Receiver operating characteristic (ROC) curves were constructed to describe the ability of the fractal dimension to discriminate between the eyes of DM, MDR, and healthy eyes. Lower values of the fractal dimension were observed in all layers in the MDR eyes compared with controls except in the inner nuclear layer (INL). Lower values of the fractal dimension were also found in all layers in the MDR eyes compared with DM eyes. The highest area under receiver operating characteristic curve (AUROC) values estimated for the fractal dimension were observed for the outer plexiform layer (OPL) and outer segment photoreceptors (OS) when comparing MDR eyes with controls. The highest AUROC value estimated for the fractal dimension were also observed for the retinal nerve fiber layer (RNFL) and OS when comparing MDR eyes with DM eyes. Our results suggest that fractal dimension of the intraretinal layers may provide useful information to differentiate pathological from healthy eyes. Further research is warranted to determine how this approach may be used to aid diagnosis of retinal neurodegeneration at the early stage.
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