The corresponding author Mushtaq Ahmed was added on 3/12/2009.Introduction: Bangladesh is a developing country of South Asia. Rural population of this country is mostly dependant on agricultural cultivations. With the advance of times, pesticides are, now a days routinely used for modern cultivation method. These are readily available as over the counter (OTC) drugs in village shops and act as a common agent for suicidal purpose after trivial family problems. Currently pesticide self poisoning has become a major clinical problem of the developing countries killing around 3,00,000 people each year. Industrialized countries are also affected by it, where a significant proportion of suicidal death are caused by Pesticide ingestion. Of course, such poisoning is seldom included as a priority for heath research in this country. doi: 10.3329/jafmc.v5i1.2851 JAFMC Bangladesh. Vol 5, No 1 (June) 2009 pp.41-45
This cross sectional descriptive study was conducted to observe the quality of Pharmacology professional written question papers of Bangladesh University of Professionals (BUP), University of Chittagong (CU), University of Dhaka (DU), Rajshahi University (RU) and Shahjalal University of Science & Technology (SUST).For this purpose total 82 SAQ papers of five universities dated from January 2007 to July 2015 were reviewed. Question papers were reviewed to find out the coverage of recall, understanding and problem solving type questions, content coverage and presence of marking scheme in SAQ papers.Mean percentage of recall, understanding and problem questions were 54.3%, 44% and 01.7% respectively in SAQ papers. Mean of the recall questions of SUST statistically significantly differed from curriculum standard 60%. Other universities had no significant differences with the standard. Mean of the understanding questions of all the universities statistically significantly differed from curriculum standard 30% except BUP. There was statistically significant difference between mean of the problem solving questions of all the universities and curriculum standard 10% .Most of the SAQ papers (62%) were without problem based questions. No question paper was found having different types question as per curriculum standard.Total 15(18.3%) SAQ papers contained 100 % topics (all the 11 groups). Thirty nine (47.6) contained 10 groups and 22% contained 9 groups out of 11. Twelve percent SAQ papers contained less 80% topics Total 29 (35.4%) SAQ papers of all the universities showed marking scheme on the questions papers, rest 64.6% were devoid of it. Maximum 87.5% SAQ papers of RU had marking scheme.Findings of this study may be used to redefine the distribution of different types question in SAQ papers and to improve the quality of question papers by ensuring their coverage.
The objective of this study was to prepare poly(DL-lactide-co-glycolide) (PLGA) microspheres containing guanosine as a model drug for intraocular administration. Microspheres were prepared by solvent evaporation technique using o/w emulsion system. The influence of composition and molecular weight of PLGA, drug loading efficiency, microsphere size, and in vitro and in vivo release rates were determined. Differential scanning calorimetry (DSC) and FTIR studies were conducted to examine the guanosine-polymer interaction. In vitro release studies indicated that the permeant release from microspheres exhibits an initial burst followed by slow first-order kinetics. Ascending molecular weights of the polymers generated progressively slower release rates. Three different sizes of microspheres were prepared. The release continued for 7 days with a maximum of 70% of the content released within that time period. DSC and FTIR studies showed no polymer-guanosine interaction. A novel microdialysis technique was used to examine the initial release kinetics from microspheres in isolated vitreous humor. This technique was also employed to observe in vivo intravitreal release in albino rabbits. A good correlation exists between in vitro and in vivo release rates from both 75 and 140 kDa PLGA microspheres. Guanosine-loaded microspheres could be prepared for once-a-week intravitreal injection with minimum required concentration maintained throughout the dosing interval. Because the structural and solubility characteristics of guanosine are similar to those of acyclovir and ganciclovir (two acycloguanosine analogues effective against herpes simplex virus [HSV-1] and cytomegalovirus [CMV], respectively), similar biodegradable polymer-based microsphere technology can be employed for the long-term intraocular delivery of these two drugs.
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