Five pharmaceutical materials, including two salts and three
neutral compounds, have been subjected to nanoindentation
analysis on a single-crystal scale. The nanoindentation experiments were used to calculate a brittleness index for each of the
five materials. These results were compared to the size reductions that were obtained on a pilot-plant scale mill. A good
correlation between single crystal and large pilot-plant scale
results was obtained for the range of materials studied.
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