Hemorrhagic stroke and brain microbleeds are caused by cerebrovascular ruptures. Fast repair of such ruptures is the most promising therapeutic approach. Due to a lack of high-resolution in vivo real-time studies, the dynamic cellular events involved in cerebrovascular repair remain unknown. Here, we have developed a cerebrovascular rupture system in zebrafish by using multi-photon laser, which generates a lesion with two endothelial ends. In vivo time-lapse imaging showed that a macrophage arrived at the lesion and extended filopodia or lamellipodia to physically adhere to both endothelial ends. This macrophage generated mechanical traction forces to pull the endothelial ends and facilitate their ligation, thus mediating the repair of the rupture. Both depolymerization of microfilaments and inhibition of phosphatidylinositide 3-kinase or Rac1 activity disrupted macrophage-endothelial adhesion and impaired cerebrovascular repair. Our study reveals a hitherto unexpected role for macrophages in mediating repair of cerebrovascular ruptures through direct physical adhesion and mechanical traction.

Dental Caries is a kind of chronic oral disease that greatly threaten human being’s health. Though dentists and researchers struggled for decades to combat this oral disease, the incidence and prevalence of dental caries remain quite high. Therefore, improving the disease management is a key issue for the whole population and life cycle management of dental caries. So clinical difficulty assessment system of caries prevention and management is established based on dental caries diagnosis and classification. Dentists should perform oral examination and establish dental records at each visit. When treatment plan is made on the base of caries risk assessment and carious lesion activity, we need to work out patient‑centered and personalized treatment planning to regain oral microecological balance, to control caries progression and to restore the structure and function of the carious teeth. And the follow-up visits are made based on personalized caries management. This expert consensus mainly discusses caries risk assessment, caries treatment difficulty assessment and dental caries treatment plan, which are the most important parts of caries management in the whole life cycle.

On the basis of a unique nucleophilic addition reaction, a novel water-soluble broadly emitting (500-700 nm) fluorescent Probe 1 was developed for the rapid detection of SO2 derivatives in aqueous media. The positively-charged benzopyrylium moiety in Probe 1 provides both excellent water solubility, making this probe applicable in 100% aqueous environments, and the ability to function as a fluorescence quencher of the coumarin moiety. Probe 1 generates a nearly instantaneous strong fluorescence signal in response to SO2 derivatives having an 8.3 nM detection limit for bisufite. The resulting Probe 1-sulfite adduct emits in the green/red spectral region (λ(max) = 585 nm) with a large Stokes shift (139 nm). The probe exhibits excellent selectivity toward SO2 derivatives over other potential interfering agents including reactive sulfur-containing species. Importantly, we demonstrate that Probe 1 can be used for the real-time sensing and bioimaging of SO2 derivatives in living cells.

Objective: To compare the esthetic improvement between postorthodontic white-spot lesions (WSLs) treated by resin infiltration and microabrasion for 12 months. Materials and Methods: A total of 20 patients with 128 teeth with postorthodontic WSLs were recruited. A simple randomized, split-mouth, positive controlled design was used to allocate patients to resin infiltration or microabrasion groups. The lesion area ratio (R value) was calculated between the area of a WSL and the labial surface of the corresponding tooth based on standardized clinical photographs. The color change (ΔE) of each tooth was measured with a Crystaleye spectrophotometer (Olympus, Tokyo, Japan). Every measurement was taken before treatment (T0) and at different time points after treatment: 1 week (T1), 6 months (T6), and 12 months (T12). Results: A total of 16 patients with 108 trial teeth were available at T12. Each group had 54 trial teeth. In both groups, there was a significant decrease in R value and ΔE between T1 and T0 (P < .0001). In the infiltration group, the R value and ΔE had no significant changes over time from T1 to T12. In the microabrasion group, the R value and ΔE decreased significantly from T1 to T6. The R value of resin infiltration was lower when compared with microabrasion at every recall point (P < .001). The ΔE had no significant differences between the two groups at any timepoint. Conclusions: Resin infiltration and microabrasion improved the esthetic appearance of WSLs and showed sufficient durability for 12 months. Resin infiltration showed a better esthetic improvement effect when compared with microabrasion at 12 months.

Currently, constructing ternary organic solar cells (OSCs) and developing nonfullerene small molecule acceptors (n‐SMAs) are two pivotal avenues to enhance the device performance. However, introducing n‐SMAs into the ternary OSCs to construct thick layer device is still a challenge due to their inferior charge transport property and unclear aggregation mechanism. In this work, a novel wide band gap copolymer 4,8‐bis(4,5‐dioctylthiophen‐2‐yl) benzo[1,2‐b:4,5‐b′]dithiophene‐2,6‐diyl‐alt‐N‐(2‐hexyldecyl)‐5,5′‐bis(thiophen‐2‐yl)‐2,2′‐bithiophene‐3,3′‐dicarboximide (PDOT) is designed and blend of PDOT:PC71BM achieves a power conversion efficiency (PCE) of 9.5% with active layer thickness over 200 nm. The rationally selected n‐SMA based on a bulky seven‐ring fused core (indacenodithieno[3,2‐b]thiophene) end‐capped with 2‐(3‐oxo‐2,3‐dihydroinden‐1‐ylidene) malononitrile groups (ITIC) is introduced into the host binary PDOT:PC71BM system to extend the absorption range and reduce the photo energy loss. After fully investigating the morphology evolution of the ternary blends, the different aggregation behavior of n‐SMAs with respect to their fullerene counterpart is revealed and the adverse effect of introducing n‐SMAs on charge transport is successfully avoided. The ternary OSC delivers a PCE of 11.2% with a 230 nm thick active layer, which is among the highest efficiencies of thick layer OSCs. The results demonstrate the feasibility of using n‐SMAs to construct a thick layer ternary device for the first time, which will greatly promote the efficiency of thick layer ternary devices.