A hybrid hydrogel composed of gelatin and gold nanoparticles (GNPs) was designed to evaluate the effect of new bone formation and proves itself to be useful as an implant material for treating defected bone tissues.
The iron ore sintering was characterized as a relatively uniform process of solid material, coke combustion, various modes of heat transfer, and the complicated physical changes of solid particles. The sintering bed was modeled as an unsteady one-dimensional process of the solid materials with multiple solid phases, which confers a phase on each kind of solid material. Each solid phase had a specific particle size and compositions. Drying, condensation, coke combustion, limestone decomposition, generation of the macroscopic internal pore and shrinking of the bed were considered. Complicated modes of heat transfer including conduction, convection and radiation were considered. Numerical simulations of the condition in the iron ore sintering bed were carried out for various parameters: coke contents and air suction rates, along with some other parameters of the model. Calculation results were compared with the results of the sintering pot test. The temperature profiles and gas compositions showed a good agreement with the experimental data.KEY WORDS: iron ore sintering; mathematical model; multiple solid phase; coke combustion; heat transfer.
Surface-modified titanium (Ti) samples with hydroxyapatite (HAp) and heparin (Hep)-bone morphogenetic protein-2 (BMP-2) complex (Ti/HAp/Hep/BMP-2) were prepared, and their efficacies on the enhancements of bone formation and osseointegration in vitro and in vivo were examined as compared to Ti/HAp and Ti/Hep/BMP-2. The modified surfaces were characterized by X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and contact angle goniometry. In vitro studies revealed that MG-63 human osteosarcoma cell lines grown on Ti/HAp/Hep/BMP-2 increased the amounts of alkaline phosphatase (ALP) activity, calcium deposition and the levels of OCN mRNA gene expression as compared to those grown on Ti/HAp, Ti/Hep/BMP-2 or pristine Ti. Moreover, Ti/HAp/Hep/BMP-2 exhibited higher bone volume (BV), bone volume/tissue volume (BV/TV), removal torque value and bone-implant contact (BIC) than Ti/HAp, Ti/Hep/BMP-2 or pristine Ti in vivo. Histological evaluations showed that many desirable features of bone remodelling existed at the interface between Ti/HAp/Hep/BMP-2 and the host bone. Consequently, Ti/HAp/Hep/BMP-2 may have potential for clinical use as dental or orthopaedic implants.
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