Some experiments which are done on the effect of saffron extract and its constituents on different aspects of morphine dependency in different geographical regions have shown that the extract of saffron, as well as its crocin constituent, are effective in the prevention of withdrawal signs in morphinedependent mice. 2 However, because the previous studies have shown that climate changes, geographical situations, and many other factors, make a great impact on the composition of a plant and thereby on its biological activity, 3,24 this question comes up that Afghan native saffron despite its impression by climate and geographical conditions, what effects will it have on withdrawal signs in morphine-dependent rats. This study wants to focus on this question, so, is going to investigate the effect of aqueous extract of Afghan saffron on morphine-dependent rats, using the behavioral method of counting the naloxoneinduced withdrawal signs.
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