Electrical Impedance Tomography (EIT) is an image reconstruction technique applied in medicine for the electrical imaging of living tissues. In literature there is the evidence that a large resistivity variation related to the differences of the human tissues exists. As a result of this interest for the electrical characterization of the biological samples, recently the attention is also focused on the identification and characterization of the human tissue, by studying the homogeneity of its structure. An 8 electrodes needle-probe device has been developed with the intent of identifying the structural inhomogeneities under the surface layers. Ex-vivo impeditivity measurements, by placing the needle-probe in 5 different patterns of fat and lean porcine tissue, were performed, and impeditivity maps were obtained by EIDORS open source software for image reconstruction in electrical impedance. The values composing the maps have been analyzed, pointing out a good tissue discrimination, and the conformity with the real images. We conclude that this device is able to perform impeditivity maps matching to reality for position and orientation. In all the five patterns presented is possible to identify and replicate correctly the heterogeneous tissue under test. This new procedure can be helpful to the medical staff to completely characterize the biological sample, in different unclear situations.
Bioimpedance allows living tissues characterization and detection of pathological states. Although in previous years several methods have been proposed to assess bioimpedance, many instruments used in studies of living tissues characterization are commercial devices designed for the measurement of components or electronic circuits and therefore the measurement of biological tissues can be affected by electrical polarization. In order to test if electrical impedance spectroscopy may be helpful in providing further information about the structure and the properties of tissues, an impedance meter for living-tissues, able to avoid polarization, was developed. Subsequently, ex-vivo impedance measurements were performed by placing a needle-probe into 6 tissues (heart, kidney, lung, muscle, liver and fat) of 3 rabbits. Impedance was analyzed in terms of modulus and phase. In the range 2-10 kHz, considering both modulus and phase, it was possible to discriminate each tissue with statistical significance. In the lower considered range of frequencies (i.e., 10-100 Hz and 200-1000 Hz) this was not always the case. We conclude that the detailed analysis of modulus and phase in the frequency range of 2-10 kHz, by using an ad-hoc device able to avoid electrical polarization, allows to discriminate between several healthy living tissues.
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