CIDP has important social and economic impacts, owing to functional impairments that can lead to professional and personal limitations.

Staphylococcus aureus is able to rapidly develop mechanisms of resistance to various drugs and to form strong biofilms, which makes it necessary to develop new antibacterial drugs. The essential oil of Melaleuca alternifolia is used as an antibacterial, a property believed to be mainly due to the presence of terpinen-4-ol. Based on this, the objective of this study was to evaluate the antibacterial and antibiofilm potential of terpinen-4-ol against S. aureus. The Minimal Inhibitory and Minimal Bactericidal Concentrations (MIC and MBC) of terpinen-4-ol were determined, and the effect of its combination with antibacterial drugs as well as its activity against S. aureus biofilms were evaluated. In addition, an in silico analysis of its pharmacokinetic parameters and a molecular docking analysis were performed. Terpinen-4-ol presented a MIC of 0.25% (v/v) and an MBC of 0.5% (v/v) (bactericidal action); its association with antibacterials was also effective. Terpinen-4-ol has good antibiofilm activity, and the in silico results indicated adequate absorption and distribution of the molecule in vivo. Molecular docking indicated that penicillin-binding protein 2a is a possible target of terpinen-4-ol in S. aureus. This work highlights the good potential of terpinen-4-ol as an antibacterial product and provides support for future pharmacological studies of this molecule, aiming at its therapeutic application.

Candida albicans is an important opportunistic fungal pathogen capable of provoking infection in humans. In the present study, we evaluated the antifungal effect of 23 ester derivatives of the cinnamic and benzoic acids against 3 C. albicans strains (ATCC-76645, LM-106 and LM-23), as well as discuss their Structure-Activity Relationship (SAR). The antifungal assay results revealed that the screened compounds exhibited different levels of activity depending on structural variation. Among the ester analogues, methyl caffeate (5) and methyl 2-nitrocinnamate (10) were the analogues that presented the best antifungal effect against all C. albicans strains, presenting the same MIC values (MIC = 128 μg/mL), followed by methyl biphenyl-2-carboxylate (21) (MIC = 128, 128 and 256 μg/mL for C. albicans LM-106, LM-23, and ATCC-76645, respectively). Our results suggest that certain molecular characteristics are important for the antifungal action.

Pesticide exposure is a growing public health concern. Although Brazil is the world’s largest consumer of pesticides, only a few studies have addressed the health effects among farmers. This study aimed to evaluate whether pesticide exposure is associated with respiratory outcomes among rural workers and relatives in Brazil during the crop and off-seasons. Family farmers (82) were interviewed about occupational history and respiratory symptoms, and cholinesterase tests were conducted in the crop-season. Spirometry was performed during the crop and off-season. Respiratory outcomes were compared between seasons and multiple regressions analysis were conducted to search for associations with exposure indicators. Participants were occupationally and environmentally exposed to multiple pesticides from an early age. During the crop and off-season, respectively, they presented a prevalence of 40% and 30.7% for cough, 30.7% and 24% for nasal allergies, and 24% and 17.3% for chest tightness. Significant associations between spirometry impairments and exposure indicators were found both during the crop and off-season. These findings provide complementary evidence about the association of pesticide exposure with adverse respiratory effects among family farmers in Brazil. This situation requires special attention as it may increase the risk of pulmonary dysfunctions, and the morbidity and mortality burden associated with these diseases.

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ResumoOs estudos sobre a expressão da sexualidade das pessoas surdas são diminutos e muitas vezes não problematizam assuntos voltados às orientações afetivo-sexuais destoantes do padrão heteronormativo. A fi m de preencher a carência de pesquisas nessa área, o presente trabalho investiga as narrativas de sujeitos surdos sobre as suas primeiras experiências homossexuais e o enfrentamento do duplo preconceito; ser surdo e homossexual. Esta pesquisa se insere em uma abordagem qualitativa, tendo como instrumento metodológico a condução de entrevistas semiestruturadas. Os dados revelam que a condição homossexual entre os surdos ainda é pouco compreendida, pois há dúvidas, preconceitos e mitos acerca das experiências afetivo-eróticas. Além disso, as narrativas dos entrevistados evidenciam que a primeira relação sexual com pares de mesmo sexo, ocorrida em um ambiente próximo e relacional (doméstico e escolar) sem a anuência dos mesmos, é um marco que desencadeia os processos de constituição da sexualidade. Tais questões apontam para a necessidade de ampliação de investigações que considerem as relações entre emoção, linguagem e constituição da identidade sexual. Para além, sugere uma atenção 1 Endereço para correspondência:

A avaliação integrada da exposição a agentes químicos às condicionantes sociais, econômicas e ambientais possibilita ações efetivas e incorporadas ao espaço social, como pressupõe a metodologia de “Avaliação de Saúde Pública” da Agência de Registro de Substâncias Tóxicas e Controle de Doenças (ATSDR) e à semelhança da abordagem Ecosaúde. Assim, nosso objetivo é descrever uma experiência de avaliação de saúde pública em comunidades de agricultores familiares expostos a agroquímicos em São José de Ubá, estado do Rio de Janeiro (RJ). A sociedade civil e a esfera pública foram envolvidas no processo que reuniu informações históricas, socioeconômicas, culturais, ambientais e de saúde. A exposição ocupacional e/ou ambiental aos toxicantes ocorre em níveis que ocasionam efeitos deletérios à saúde, exigindo ações, como a prática agroecológica, educação em saúde e ambiente e requalificação dos profissionais de serviços de saúde. A abordagem tem como benefício situar o sujeito como agente integrador e influenciador de seus processos, potencializando seu empoderamento para a uma gestão ecossistêmica conjunta.

Introduction: the multifactorial nature of motor development is reinforced by the combination of biological and environmental risk factors, which intensify the chances of impaired motor development. Objectives: to verify the relationship between functional mobility skills of children with risk factors and motor stimulus opportunities in their home environment. Methods: transversal study conducted with 112 patients aged 18-42 months from follow-up services. Motor stimulus opportunities were evaluated by the Affordance in the Home Environment for Motor Development (AHEMD-SR) and Functional mobility skills by the Pediatric Evaluation Disability Inventory (PEDI). Student t test and multiple linear regression analysis were carried out. Results: predominance of good performance of functional mobility skills and "average level" of environmental stimulus opportunities were observed. There was no significant association between HFM-PEDI and AHEMD-SR. The results showed significant association only between HFM-PEDI and presence of health problems (p = 0.004). Children with health problems had lower mean PEDI normative score. Multiple linear regression analysis showed significant result for health problems in the interaction among environment, control variables and HFM-PEDI (p = 0.003). Conclusion: there was no association between functional mobility skills of children with risk factors and motor stimulus opportunities in their home environment. On the other hand, children with some health problem showed lower performance in functional mobility skills.