No. 5 MOUSE COLON TUMOR MODEL 9 Corbett et al.
2661* Dosage conversion: to convert mg/kg in the mouse to mg/m* in humans, multiply by 3. That is, a dose of 5 mg/kg in the mouse is equal to 15 mg/m' in humans. (c,
OI
Colon tumors of mice were induced with 1, 2‐dimethylhydrazine, N‐nitroso‐N‐methylurethane, methylnitrosourea, and 4‐methyl‐N′‐nitro‐N‐nitrosoguanidine. Of 82 transplantation attempts, four were successful, and the four tumors have been maintained as distinct tumor lines by subcutaneous transplantation. The tumors graded from II, adenocarcinoma, to IV, undifferentiated carcinoma. Volume‐doubling times varied over a three‐fold range, and metastatic potential ranged from 5 to about 100%. The tumors responded to treatment with some of the same agents found to be active in man. These included cyclophosphamide, 5‐fluorouracil, and certain nitrosoureas. Preliminary evidence suggests that these tumor lines may be useful as experimental models.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.