| INTRODUC TI ONDermatophyte infections are a type of infection produced by different groups of pathogenic fungi for humans and some animals. These fungi can invade keratinised structures such as the stratum corneum, hair and nails. 1,2 Dermatophytosis is among the most frequently diagnosed skin infections worldwide. 3,4 It is produced by dermatophytes that can digest and use keratin as a substrate, comprising seven genera with four being recognised as affecting human beings, namely, Trichophyton, Microsporum, Nannizzia or Epidermophyton. 5 These can be classified, according to their habitat, as anthropophilic, geophilic and zoophilic. In studies conducted in Latin America, the five most frequent dermatophytes in the general population were Trichophyton rubrum (70%), Microsporum canis (13%), Trichophyton mentagrophytes Summary Background: Dermatophytosis is one of the most frequent superficial mycoses in the world. Main aim: To describe the cases of skin dermatophytosis and its main aetiologic agents in patients referred to a Mycological Reference Laboratory in Medellín, Colombia. Methods: A retrospective study was carried out with records of patients referred between 1994 and 2016 to the Corporación para Investigaciones Biológicas (CIB), Medellín-Colombia, because of clinical suspicion of skin dermatophytosis. Results: Of a total of 5628 clinical records of patients with suspicion of skin dermatophytosis analysed, 2780 (49.4%) had a proven or probable dermatophytosis diagnosis, 2774 cultures were performed, and aetiologic agents were isolated in 2576 samples (92.9%). The most frequently isolated aetiologic agents were Trichophyton rubrum (44.3%), followed by Trichophyton mentagrophytes complex (33.3%), Epidermophyton floccosum (12.4%), Nannizzia gypseum complex (5.7%, formerly Microsporum gypseum),Microsporum canis (3.5%) and Trichophyton tonsurans (0.8%). The most frequent clinical forms were tinea pedis (72.7%) and tinea corporis (12.7%). In addition, a group of patients (0.9%) developed mixed infections by two dermatophyte agents and another (4.1%) developed infections in more than one anatomical site. Conclusions:The results of the present study are coherent with previous reports where T rubrum and T mentagrophytes complex were the main causative agents of dermatophytosis. However, the increased incidence of N gypsea complex over M canis is worth highlighting. K E Y W O R D Sdermatophytosis, Epidermophyton, Microsporum, Nannizzia, tinea, Trichophyton | 495 CARRASCAL-CORREA Et AL.
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