An electrochemical sensor for sensitive detection of paracetamol (PCM) was developed by constructing the glassy carbon electrode (GCE) modified with multiwalled carbon nanotubecetyltrimethyl ammonium bromide (MWCNT-CTAB). Modification improves the redox kinetics of PCM with increased current intensity. A similar modification at CTAB modified GCE did not result in an impressive charge transfer. Detection limit of PCM was determined from differential pulse voltammetric (DPV) study and found to be 4.82×10 −9 M with a linear dynamic range of 4.0×10 −7 M to 4.0×10 −6 M. The interference studies showed that the modified electrode exhibits excellent selectivity in the presence of large excess of interferents and response is fast, stable, reliable, resistant to biofouling and can be applied for the real sample analysis in medical, pharmaceutical and biotechnological sectors.Kinetic parameters were determined using electrochemical approaches. The practical analytical application of this electrode was demonstrated by measurement of PCM content in PYREMOL 650 tablet and real sample analysis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.