(Gut 1998;42:711-714)

Results-There were 12 colorectal cancers. Six cancers were diagnosed prior to the diagnosis of PSC. Among the 104 patients with an intact colon at the time of the diagnosis of PSC there was a cumulative risk for colorectal cancer of 16% after 10 years. Among the 58 patients with a diagnosis of ulcerative colitis and colorectal cancer prior to the diagnosis of PSC, there were five colorectal cancers corresponding to a cumulative risk of 25% after 10 years. Conclusions-Patients with ulcerative colitis and concomitant PSC seem to constitute a subgroup with a high risk for colorectal cancer. (Gut 1997; 41: 522-525) Keywords: ulcerative colitis; primary sclerosing cholangitis; colorectal cancer Patients with ulcerative colitis have an increased risk of colorectal cancer. The magnitude of this risk varies in diVerent studies with a range in cumulative risk of between 1% and 3% 10 years after diagnosis in patients with pancolitis and around 10% after 20 years.

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Patients with PSC have a substantially decreased survival, which is most pronounced among patients without IBD.