In situ photopolymerized hydrogel dressings create minimally invasive methods that offer advantages over the use of preformed dressings such as conformability in any wound bed, convenience of application, and improved patient compliance and comfort. Here, we report an in situ-formed hydrogel membrane through ultraviolet cross-linking of a photocross-linkable azidobenzoic hydroxypropyl chitosan aqueous solution. The hydrogel membrane is stable, flexible, and transparent, with a bulk network structure of smoothness, integrity, and density. Fluid uptake ability, water vapor transmission rate, water retention, and bioadhesion of the thus resulted hydrogel membranes (0.1 mm thick) were determined to range from 97.0-96.3%, 2,934-2,561 g/m(2)/day, 36.69-22.94% (after 6 days), and 4.8-12.3 N/cm(2), respectively. These data indicate that the hydrogel membrane can maintain a long period of moist environment over the wound bed for enhancing reepithelialization. Specifically, these properties of the hydrogel membrane were controllable to some extent, by adjusting the substitution degree of the photoreactive azide groups. The hydrogel membrane also exhibited barrier function, as it was impermeable to bacteria but permeable to oxygen. In vitro experiments using two major skin cell types (dermal fibroblast and epidermal keratinocyte) revealed the hydrogel membrane have neither cytotoxicity nor an effect on cell proliferation. Taken together, the in situ photocross-linked azidobenzoic hydroxypropyl chitosan hydrogel membrane has a great potential in the management of wound healing and skin burn.
This paper presents analytical technique and simplified formulas for the calculations of cracking, yield and ultimate moments of different cases as well as deflections of ECC-concrete composite beams reinforced with steel bars. The technique is based on the simplified constitutive models of materials, strain compatibility, perforce bond of materials and equilibrium of internal forces and moment. Experimental testing of eleven ECC-concrete composite beams reinforced with steel bars is also presented. All beams tested had the same geometrical dimensions but different steel reinforcement strength and ECC thickness. The proposed formulas showed good agreement with the experimental results of various moment values and deflections. A parametric analysis shows that yield and ultimate moments increase with the increase of concrete strength in case of compression failure but, essentially, remain unchanged in case of tensile failure. With increasing the tensile resistance, for example by increasing ECC height replacement ratio, reinforcement ratio, strength of steel reinforcement and ECC, ultimate curvature and energy dissipation increase in case of tensile failure and decrease in case of compressive failure. On the other hand, ductility and energy dissipation ratio decrease with the increase of reinforcement ratio and strength, but, essentially, remain unchanged with increasing the height replacement ratio and strength of ECC.
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