Abstract. This paper presents the first data evaluation of the ESO Imaging Survey (EIS), a public survey being carried out by ESO and member states, in preparation for the VLT first-light. The survey goals, organization, strategy and observations are discussed and an overview is given of the survey pipeline developed to handle EIS data and produce object catalogs. A report is presented on moderately deep I-band observations obtained in the first of four patches surveyed, covering a region of 3.2 square degrees centered at α ∼ 22 h 40 m and δ = −40• . The products available to the community, including pixel maps (with astrometric and photometric calibrations) and the corresponding object catalogs, are also described. In order to evaluate the quality of the data, preliminary estimates are presented for the star and galaxy number counts, and for the angular two-point correlation function obtained from the available data. The present work is meant as a preview of the final release of the EIS data that will become available later this year.
BackgroundHIV-infected individuals have deficient responses to Yellow Fever vaccine (YFV) and may be at higher risk for adverse events (AE). Chronic immune activation–characterized by low CD4/CD8 ratio or high indoleamine 2,3-dioxygenase-1 (IDO) activity—may influence vaccine response in this population.MethodsWe prospectively assessed AE, viremia by the YFV virus and YF-specific neutralizing antibodies (NAb) in HIV-infected (CD4>350) and -uninfected adults through 1 year after vaccination. The effect of HIV status on initial antibody response to YFV was measured during the first 3 months following vaccination, while the effect on persistence of antibody response was measured one year following vaccination. We explored CD4/CD8 ratio, IDO activity (plasma kynurenine/tryptophan [KT] ratio) and viremia by Human Pegivirus as potential predictors of NAb response to YFV among HIV-infected participants with linear mixed models.Results12 HIV-infected and 45-uninfected participants were included in the final analysis. HIV was not significantly associated with AE, YFV viremia or NAb titers through the first 3 months following vaccination. However, HIV–infected participants had 0.32 times the NAb titers observed for HIV-uninfected participants at 1 year following YFV (95% CI 0.13 to 0.83, p = 0.021), independent of sex, age and prior vaccination. In HIV-infected participants, each 10% increase in CD4/CD8 ratio predicted a mean 21% higher post-baseline YFV Nab titer (p = 0.024). Similarly, each 10% increase in KT ratio predicted a mean 21% lower post-baseline YFV Nab titer (p = 0.009). Viremia by Human Pegivirus was not significantly associated with NAb titers.ConclusionsHIV infection appears to decrease the durability of NAb responses to YFV, an effect that may be predicted by lower CD4/CD8 ratio or higher KT ratio.
ART-treated HIV-infected individuals seem to have impaired and/or less durable responses to YFV than HIV-uninfected individuals, which were associated with lower CD4(+)/CD8(+) ratio, but not with CD4(+) T-cell count. These results supports the notion that low CD4(+)/CD8(+) ratio, a marker linked to persistent immune activation, is a better indicator of functional immune disturbance than CD4(+) T-cell count in patients with successful ART.
A sample of Large Magellanic Clouds (LMC) and Small Magellanic Clouds (SMC) clusters for which ages have been directly determined from main sequence turnoff photometry has been compiled. According to this sample, the LMC and SMC cluster age distributions are very different. The LMC contains a large population of 1 to 3 Gyr old clusters as well as a small number of clusters that appear to be as old as the Galactic halo globular clusters. Surprisingly however, only a single cluster is known with an age in the interval between 3 Gyr and the age, taken as 15 Gyr, of the oldest clusters. The SMC age distribution, on the other hand, is much broader. It extends back to approximately 12 Gyr but there appear to be no SMC clusters as old as the oldest in the LMC. The sample of clusters is also used to discuss the age-abundance relations for both galaxies. Little can be learned for the LMC but it appears that the chemical evolution of the SMC differed in form from that experienced in the solar neighbourhood. The first results of an imaging survey designed to find LMC clusters with ages exceeding 3 Gyr are also described.
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