Membrane depolarization is caused by both gradual and rapid ventricular stretch, but PVEs are more easily elicited by rapid stretch. Regions of greater myocardial compliance that experience greater relative stretch may act as "foci" for stretch-activated arrhythmias during dynamic ventricular loading. These whole-heart data corroborate the existence of stretch-activated membrane channels in ventricular myocardium and may help explain ventricular ectopy under conditions of differential ventricular loading, as in ventricular dyskinesia, or regional muscle traction, as in mitral valve prolapse syndrome.
EDEB-TACE groups was 91.2 days and 153.6 days respectively (p ¼ 0.34). No significant differences between the groups regarding doxorubicin dose, age, sex, BCLC staging, portal vein invasion, liver function (Child-Pugh) or tumor grading. The mean percent tumor necrosis at explant for the DEB-TACE group was 74.7% (range 5-100%, STD 32.3) and for the EDEB-TACE 93% (range 70-100%, STD 11) P ¼ 0.18. There was no significant difference in treatment related liver toxicity. Conclusions: Adding ethiodized oil to existing DEB-TACE regimens is safe and showed a trend towards increased tumor necrosis at explant histology. More studies with larger sample sizes are necessary to further evaluate this hypothesis.
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