Keywords: 3-aminopyrrolidin-2-ones, methyl esters of 1H-pyrazoline-3-carboxylic acids, Raney nickel, catalytic hydrogenation, cyclocondensation.At the present time much attention is paid to the search for new regioselective and stereoselective methods for constructing the pyrrolidine ring, which is a pharmacophoric group of many pharmaceutical preparations (piracetam, oxiracetam, fenotropil) and physiologically active substances (domoic acid, oxazolomycin) [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Pyrrolidines with an amino group in position 3 are of special interest. For example, 3-aminopyrrolidin-2-one, linked with a norbornane fragment, displays antiarrhythmic, anti-inflammatory, analgesic, and nootropic activity and in the breadth of its therapeutic action exceeds the antiarrhythmic preparations used at the present time [15,16].The use of 1,3-dipolar cycloaddition of diazo compounds to olefins and subsequent catalytic hydrogenation of the resulting pyrazolinecarboxylic acid esters is one of the most promising approaches to the synthesis of 3-aminopyrrolidin-2-ones [15][16][17][18].With the aim of obtaining new compounds of the series mentioned the hydrogenation has been studied in the present work of pyrazoline-3-carboxylic acid methyl ester (1), and also its 4-phenyl-(2), 5-methoxycarbonyl-(3), 4-methoxycarbonyl-(4), and 4,5-di(methoxycarbonyl)-(5) substituted analogs.
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