Patients with chronic unhealing wounds showed substantial improvement when treated with PLT gel lesion dressings.

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Thyroid hormone serum concentrations, the thyrotropin (TSH) and prolactin (PRL) response to thyrotropin-releasing hormone (TRH) were evaluated in patients undergoing cardiopulmonary bypass (CPB) conducted in hypothermia. During CPB a marked decrease of thyroxine (T₄) and triiodothyronine (T₃) concentration with a concomitant increase of reverse T₃ (rT₃) were observed similarly to other clinical states associated with the ‘low T₃ syndrome’. Furthermore, in the present study elevated FT₄ and FT₃ concentrations were observed. In a group of patients, TRH administered during CPB at 26°C elicited a markedly blunted TSH response. In these patients, PRL concentration was elevated but did not significantly increase after TRH. The increased concentrations of FT₄ and FT₃ were probably due to the large doses of heparin administered to these patients. Thus, the blunted response of TSH to TRH might be the consequence of the elevation of FT₄ and FT₃ in serum, however, other factors might play a role since also the PRL response to TRH was blocked.

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