Acta psychiatr. scand: 80 (supp. 350): [93][94] Paroxetine: lack of effect metabolizing enzymes Paroxetine is eliminated from the body by hepatic metabolism, the same metabolic pathway being used by both rodents and man. The ability of paroxetine to modify the activity of drug metabolizing enzymes has been studied directly in rats at the relatively high oral dose level of SOmglkg, and indirectly in healthy subjects at a dose level likely to be used in therapy.
Methods
Animal experimentsRats were dosed orally with paroxetine, SOmglkgper day for eight days, and on the ninth day hepatic drug metabolizing activity was studied ex vivo. Protein and cytochrome P-450 content, and metabolizing activity against 2. Fouts JR. Liver smooth endoplasmic reticulum microsomes drug metabolising enzyme system. Methods in Pharmacology
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