Introduction Bladder cancer is a possible outcome of chronic urinary schistosomiasis in many endemic countries. In Tanzania, the Lake Victoria area is one of the areas with the highest prevalence of urinary schistosomiasis and higher incidences of squamous cell carcinoma (SCC) of the urinary bladder. A previous study in the area over one decade (2001–2010) showed SCC to be common in patients aged below 50 years. With various prevention and intervention programs there are likely to be notable changes in schistosomiasis-related urinary bladder cancer, which is currently unknown. Updated information on the status of SCC in this area will be useful for giving an insights into efficacy of control interventions implemented and help guide the initiation of new ones. Therefore, this study was done to determine the current trend of schistosomiasis-related bladder cancer in lake zone, Tanzania. Methods This was a descriptive retrospective study of histologically confirmed urinary bladder cancer cases diagnosed at the Pathology Department of Bugando Medical Centre over 10 years period. The patient files and histopathology reports were retrieved and information was extracted. Data were analyzed using Chi-square and student t-test. Results A total of 481 patients were diagnosed with urinary bladder cancer during the study period whereby, 52.6% were males and 47.4% were females. The mean age regardless of histological type of cancer was 55 ± 14.2 years. The SCC was the commonest histological type accounting for 57.0%, followed by transitional cell carcinoma 37.6%, and 5.4% were adenocarcinomas. The Schistosoma haematobium eggs were observed in 25.2% and were commonly associated with SCC (p = 0.001). Poorly differentiated cancers were observed mostly in females (58.6%) compared to males (41.4%) (p = 0.003). Muscular invasion of the urinary bladder by cancer was observed in 11.4% of the patients, and this was significantly higher in non-squamous than in squamous cancers (p = 0.034). Conclusion Schistosomiasis-related cancers of the urinary bladder in the Lake zone of Tanzania is still a problem. Schistosoma haematobium eggs were associated with SCC type indicating the persistence of infection in the area. This calls for more efforts on preventive and intervention programs to reduce the burden of urinary bladder cancer in the lake zone.
Long-term infections by urinary schistosomiasis can result in urinary tract morbidities and increase the threats to public health. Information on the community’s knowledge, attitudes, and practices (KAP) on various aspects of urinary schistosomiasis, caused by Schistosoma haematobium has been lacking in Itilima District, which is likely to perpetuate the transmission of the disease and its negative health consequences. This study assessed knowledge, attitudes and practices on schistosomiasis-related morbidities in Itilima District from February to June 2021. A cross-sectional survey using a structured questionnaire was used, and a total of 657 participants were involved in the study. A total of 575 participants (87.5%) had awareness on schistosomiasis compared to 82 (12.5%) who were not aware of the disease, and this variation was statistically significant (x² = 369.938, DF = 1, p < 0.001). The relationship between urinary schistosomiasis and its related morbidities was known by 111 (16.9%) respondents, while 546 (83.1%) knew nothing about it, and this variation was also statistically significant (c2 = 388.166, DF = 1, p < 0.001). It can be concluded that knowledge of urinary schistosomiasis and its related morbidities among the communities was limited. This is possibly because knowledge of infection stages of S. haematobium that causes the morbidity requires an understanding of disease etiology. Therefore, this study recommends that interventions to impart knowledge on schistosomiasis and the associated morbidities should be implemented in Itilima District. Keywords: Schistosomiasis, Urinary tract morbidity, Knowledge, Attitudes and Practices, Itilima District
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