IntroductionThe reactive oxygen species ROS and free radicals originated in biological systems are capable of oxidizing cellular proteins, nucleic acids, and lipids leading to premature aging, mutagenesis and carcinogenesis 1 . Food vegetable products provide a wide variety of active compounds called secondary metabolites, which have antioxidant, antitumor activity, and immunostimulatory properties 2 ; the deterioration of cells in the human body can occur due to the lipid peroxidation present in aerobic cells, between the interaction of free radicals and polyunsaturated fatty acids, however, it is not the only factor that intervenes 3,4 . The Vine seeds Vitis vinífera L. have been studied due to their active properties that contain the phenolic compounds, flavonoids, and phenolic acids.

Lifestyle plays an important role in the development of noncommunicable diseases such as diabetes, hypertension, dyslipidemia, and obesity, in addition to a poor diet loaded with simple carbohydrates and saturated fats. This was a trial with a randomized, analytical, longitudinal, and prospective quasi-experimental design, which was divided into 2 phases: the first with healthy subjects with an age range between 18 to 30 y and normal BMI (18.5-24.9). The second phase was subjected with familial hypercholesterolemia aged between 18 to 45 y and overweight (25-29.9). For those subjects who frequently consumed vegetable oil of both Vitis vinifera L., or Persea americana L. (10 mL), they presented a significant reduction in anthropometric measures and in biochemical variables such as capillary glucose and increased HDLc. The vegetable oils of Persea americana L., and Vitis vinifera L., can act as adjuvants for the treatment of noncommunicable diseases.