One factor believed to impact brain resilience to the pathological damage of Alzheimer's disease (AD) is the so-called "cognitive reserve" (CR). A critical issue that still needs to be fully understood is the mechanism by which environmental enrichment interacts with brain plasticity to determine resilience to AD pathology. Previous work using PET suggests that increased brain connectivity might be at the origin of the compensatory mechanisms implicated in this process. This study aims to further clarify this issue using resting-state functional MRI. Resting-state functional MRI was collected for 11 patients with AD, 18 with mild cognitive impairment (MCI), and 16 healthy controls, and analyzed to isolate the default mode network (DMN). A quantitative score of CR was obtained by combining information about number of years of education and type of schools attended. Consistent with previous reports, education was found to modulate functional connectivity in the posterior cingulate cortex, whose disconnection with the temporal lobes is known to be critical for the conversion from MCI to AD. This effect was highly significant in AD patients, less so in patients with MCI, and absent in healthy subjects. These findings show the potential neural mechanisms underlying the individual's ability to cope with brain damage, although they should be treated with some caution based on small numbers.

Objectives/Scope Underground hydrogen storage (UHS) has been raising more interest to safely and cost-effectively store hydrogen at large-scale to help the transition from fossil fuel to sustainable energy and to achieve net-zero emission target. During hydrogen subsurface storage particularly in depleted gas reservoirs, the wellbore plays an important role in injection and reproduction to meet seasonal energy demand. However, it is still unclear how wellbore cement would react with stored hydrogen in the presence of formation brine, which may effect long-term cement integrity. We thus performed thermodynamic modelling on cement reactions with hydrogen and water at reservoirs conditions. Methods, Procedures, Process The dissolution of individual components of cement including C3S, C2S, C3A, C4AF and gypsum of Class G/H, and potential precipitation of twenty secondary minerals were simulated at an infinite time scale at reservoir temperature and pressure (representing the worst case scenario of cement degradation from geochemical perspective; in real case, the degree of cement degradation would be much less than the results from thermodynamic modelling as it is a time-dependent process). The extent of cement mineral reactions with hydrogen was compared with that of methane and carbon dioxide to assess the wellbore cement integrity during UHS compared to UGS and CCS. Results, Observations, Conclusions The cement hydration process would lead to the transformation of the major cement compositions C3S and C2S to C1.5SH (CSH) and portlandite. Adding hydrogen would only slightly change the percentage of C1.5SH and portlandite and generate a small fraction of new mineral mackinawite. As a comparison, adding methane would generate a considerable amount of calcite. When CO2 is involved, all CSH compounds would transform to calcite through the cement carbonation process. Overall, the compositional mineral phases of cement after cement hydration is more closed to the case involving H2 compared to CH4 and CO2, implying a relatively low risk of wellbore cement degradation during UHS. Novel/Additive Information Our work underlines the importance of incorporating geochemical modelling in hydrogen geo-storage evaluation when using existing old wells and new drilled wells.

Oil production from Cooper/Eromanga started in 1978, peaked in the 1980s and began a steady decline. Oil production from the Western Flank commenced in 2002 and has steadily increased. In the year until July 2014, a total of 8.6 million BBL of oil was produced from 16 active fields along the Western Flank, bringing the cumulative total to 24 million BBL. Western Flank oil has underpinned a ten-fold growth in market capitalisation in four listed Australian companies: Beach Energy, Drillsearch Ltd, Senex Energy and Cooper Energy. Two sandstone plays dominate the Western Flank petroleum geology: the Namur Sandstone low-relief structural play and the mid-Birkhead stratigraphic play. The use of 3D seismic has improved the definition of both plays, increased exploration success and optimised field appraisal and development drilling. Success rates have improved despite most Namur structural closures being close to the resolution margin for depth conversions (less than 8 m). Seismic attribute mapping is being refined in the more difficult search for mid-Birkhead stratigraphic traps with recent exploration discoveries indicating improved success. Reservoir properties in the Namur are excellent with multi-Darcy permeability, unlimited aquifer strength, low gas/oil ratio (GOR) and low residual oil saturation. This combination leads to an oil recovery factor greater than 75%. Initial free-flow production rates commonly exceed 6,000 BBL per a day. The mid-Birkhead reservoir is also of high quality but the lack of a strong aquifer drive reduces primary recovery. New and re-processed 3D seismic and water-flood projects are expected to drive further discoveries, reserve and production growth.

No abstract

The London Cancer Alliance (LCA) has developed the Quality Clinical Board Exception Report (QCBER), a tool that supports delivery of quality assurance across its member organisations through its quality assurance framework and escalation protocol. The process improves quality assurance and performance in terms of patient safety, patient satisfaction and clinical outcomes. This article describes how implementation of a robust quality assurance process supported by a simple tool can help healthcare organisations improve patient care and avoid duplication when sharing quality information among providers and across healthcare systems. It also explains how application of the tool can help organisations build evidence of best practice in the five essential Care Quality Commission areas: safety, effectiveness, care, responsiveness and good management.