The construction of three-dimensional (3D) covalent organic frameworks (COFs) remains challenging due to the limited types of organic building blocks. With octahedral Ti IV complex as the building unit, this study reports on the first 3D anionic titanium-based COF (Ti-COF-1) with an edgetransitive (6, 4)-connected soc topology. Ti-COF-1 exhibits high crystallinity, superior stability, and large specific surface area (1000.4 m 2 g À1 ). Moreover, Ti-COF-1 has a broad absorption band in the UV spectrum with an optical energy gap of 1.86 eV, and exhibits high photocatalytic activity toward Meerwein addition reactions. This research demonstrates an attractive strategy for the design of 3D functional COFs.Scheme 1. Illustration of the MOC-to-MCOF strategy for the construction of a 3D COF with soc topology.
An atmospheric-pressure N 2 -Ar plasma is investigated by means of optical emission spectroscopic diagnosis concerning the variation of its fundamental parameters, electron density and plasma temperature, and concentrations of ionized molecular nitrogen, atomic nitrogen, and excited argon with the tuning variables, such as the input power and the ratio of N 2 in N 2 -Ar mixture gas, in the discharge region of the plasma torch. Moreover, qualitative discussions are delivered with respect to the mechanisms for nitrogen dissociation and influence of the Ar component on the N 2 plasma discharge at atmospheric pressure.
Atmospheric-pressure microwave induced N 2 plasma is diagnosed by optical emission spectroscopy with respect to the plasma gas temperature. The spectroscopic measurement of plasma gas temperature is discussed with respect to the spectral line broadening of Ar I and the various emission rotational-vibrational band systems of N 2 (B-A), N 2 (C-B) andIt is found that the Boltzmann plot of the selective spectral lines from ( ) + N B-X 2 at 391.4 nm is preferable to others with an accuracy better than 5% for an atmosphericpressure plasma of high gas temperature. On the basis of the thermal balance equation, the dependences of the plasma gas temperature on the absorbed power, the gas flow rate, and the gas composition are investigated experimentally with photographs recording the plasma morphology.
Administration of bevacizumab to patients with brain metastases (BM) is controversial due to concerns about the increased risk of intracranial hemorrhage (ICH). This meta-analysis assessed whether the risk of ICH increases in BM patients receiving treatments that contain bevacizumab versus without. PubMed, Embase, Cochrane Library and annual meeting abstracts of the American Society of Clinical Oncology up to 13 November 2016 were searched for studies that referred to ICH complications due to bevacizumab in patients with BM. Eight studies involving 8713 patients were included in this analysis. Compared with the control arm without bevacizumab, the bevacizumab treatment arm did not exhibit a significant increase in ICH [odds ratio (OR) 1.20; 95% confidence intervals (CI) 0.69–2.09; P = 0.53]. Subgroup analyses with retrospective studies showed a similar result, although subgroup analyses with prospective studies failed. This meta-analysis revealed that bevacizumab does not significantly increase the risk of ICH in solid tumor patients with BM.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.