The importance of cGMP-dependent protein kinase (PKG) to the modulation of behavioural phenotypes has become increasingly clear in recent decades. The effects of PKG on behaviour have been studied in diverse taxa from perspectives as varied as ethology, evolution, genetics and neuropharmacology. The genetic variation of the Drosophila melanogaster gene, foraging (for), has provided a fertile model for examining natural variation in a single major gene influencing behaviour. Concurrent studies in other invertebrates and mammals suggest that PKG is an important signalling molecule with varied influences on behaviour and a large degree of pleiotropy and plasticity. Comparing these cross-taxa effects suggests that there are several potentially overlapping behavioural modalities in which PKG signalling acts to influence behaviours which include feeding, learning, stress and biological rhythms. More in-depth comparative analyses across taxa of the similarities and differences of the influence of PKG on behaviour may provide powerful mechanistic explications of the evolution of behaviour.

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Behaviour genetic research has shown that a given gene or gene pathway can influence categorically similar behaviours in different species. Questions about the conservation of gene function in behaviour are increasingly tractable. This is owing to the surge of DNA and 'omics data, bioinformatic tools, as well as advances in technologies for behavioural phenotyping. Here, we discuss how gene function, as a hierarchical biological phenomenon, can be used to examine behavioural homology across species. The question can be addressed independently using different levels of investigation including the DNA sequence, the gene's position in a genetic pathway, spatial-temporal tissue expression and neural circuitry. Selected examples from the literature are used to illustrate this point. We will also discuss how qualitative and quantitative comparisons of the behavioural phenotype, its function and the importance of environmental and social context should be used in cross-species comparisons. We conclude that (i) there are homologous behaviours, (ii) they are hard to define and (iii) neurogenetics and genomics investigations should help in this endeavour.

As environments change, animals update their internal representations of the external world. New information about the environment is learned and retained whereas outdated information is disregarded or forgotten. Retroactive interference (RI) occurs when the retrieval of previously learned information is less available owing to the acquisition of recently acquired information. Even though RI is thought to be a major cause of forgetting, its functional significance is still under debate. We find that natural allelic variants of the Drosophila melanogaster foraging gene known to affect rover and sitter behaviour differ in RI. More specifically, rovers who were previously shown to experience greater environmental heterogeneity while foraging display RI whereas sitters do not. Rover responses are biased towards more recent learning events. These results provide an ecological context to investigate the function of forgetting via RI and a suitable genetic model organism to address the evolutionary relevance of cognitive tasks.

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