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Objective To compare rates of detectability of circulating Rh(D)‐immunoglobulin (anti‐D) at delivery with single and two‐dose antenatal anti‐D prophylaxis (RAADP) regimens; to compare compliance with the two regimens. Design Open label, randomised controlled trial between May 2013 and November 2015. Setting, participants 277 women who attended a tertiary obstetric referral hospital in Perth for antenatal care and were at least 18 years of age, less than 30 weeks pregnant and yet to receive RAADP, Rh(D)‐negative (negative antibody screen), and who intended to deliver their baby at the hospital. Exclusion criteria were prior anti‐D sensitisation, any contraindication of anti‐D administration, and a history of isolated IgA deficiency. Interventions One 1500 IU anti‐D dose at 28 weeks of pregnancy (single dose regimen); two doses of 625 IU each at 28 and 34 weeks of pregnancy (two‐dose regimen). Main outcome measures The primary outcome was the proportion of women with detectable anti‐D levels at delivery; the secondary outcome was compliance with the allocated RAADP regimen. Results Circulating anti‐D was detectable at delivery in a greater proportion of women in the two‐dose group (111 of 129, 86%) than in the single dose group (70 of 125, 56%; P < 0.001). Compliance was not significantly different between the single dose (86 of 138, 61%) and two‐dose groups (70 of 139, 50%; P = 0.06). Conclusions The two‐dose RAADP schedule currently recommended in Australia provides better protection against Rh(D) sensitisation than a one‐dose regimen. Trial registration Australian and New Zealand Clinical Trials Registry (ACTRN12613000661774).

A B S T R A C TThe Convention on the Future of Europe that led to the eventual drafting of an EU Constitution involved numerous political actors from many countries. Their negotiations over the constitution generated a huge volume of texts containing substantive information about their preferences for EU institutional and political outcomes. In this paper, we attempt to measure these preferences at the national party level by analysing the Convention texts using the computerized 'word-scoring' method for text analysis . We then test the validity of these estimates by comparing them with measures of national party positions on EU policy dimensions obtained through an extensive expert survey undertaken in 27 countries (the EU 25 plus Turkey and Romania). Our results show strong evidence that the word-scoring method is broadly successful in reconstructing the map of national party preferences for and against a more centralized and more powerful Europe as expressed through the Convention texts.

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Communication during SBT as well as the perception of communication during actual deliveries improved across the study period. The potential of a checklist to standardize delivery room communication and improve patient outcomes merits further investigation.