T cell-mediated rejection (TCMR) in kidney transplantation, standardized by the Banff working classification, is a histologic diagnosis based on T lymphocytic infiltration of the tubules, interstitial space, and/or arterial intima and media. 1 The alloimmune basis of TCMR (including Banff Borderline) is supported by its strong correlation with degree of donor-recipient HLA-DR/DQ eplet molecular mismatch (mMM). 2 Despite modern era maintenance immunosuppression with tacrolimus (Tac) and mycophenolic acid (MPA), clinical TCMR in the first year remains between 5 and 15% documented by for-cause biopsies, while subclinical TCMR (≥Banff Borderline) occurs in up to 30% of early surveillance biopsies. [3][4][5][6]
This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.