paper describes a simple model-free (i.e., empirical) control
strategy for crystal size tuning in a continuously operated tubular
crystallizer. The crystallizer is designed for a seeded cooling crystallization
process and acetylsalicylic acid crystallization from an ethanol solution
was used as model system. Using a crystal size distribution (CSD)
analyzer and minor initial studies, we developed a feedback controller
that accurately tuned the mean crystal size within the range of 90–140
μm. In addition, we created a cleaning concept for long-term
runs based on a consistency study, which demonstrated that the CSD
of the products remained robust when process settings were kept constant.
Sufficiently small and uniform seed crystals were generated via ultrasound
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