The thermal decomposition kinetics of bezafibrate in a nitrogen atmosphere has been investigated by analyzer DTG-60. The thermal behavior of bezafibrate at the different heating rates 4, 8, 12, 16 and 20°C min -1 displays two-stage decomposition processes among 500-650 K. The activation energy (E) and pre-exponential factor (A) were calculated to be 128.72 kJ mol -1 and 3.56 9 10 10 min -1 by Flynn-Wall-Ozawa, KissingerAkahira-Sunose, Doyle, Kissinger and Šatava-Š esták methods for the second-stage decomposition process. The results show that the non-isothermal thermal decomposition mechanism of bezafibrate is classified as three-dimensional diffusion model, and the integral and differential equations are gðaÞ ¼ ½1 À ð1 À aÞ 1=3 2 and f ðaÞ ¼ 3 2 1 À a ð Þ 2=3The enthalpy (DH = ), entropy (DS = ) and Gibbs free energy (DG = ) were calculated to be 123.74 kJ mol -1 , -91.07 J mol -1 K -1 and 178.29 kJ mol -1 , respectively.Keywords Bezafibrate Á Kinetics Á Thermal decomposition Á Thermodynamical analysisList of symbols A Pre-exponential factor (min -1 ) E Activation energy (kJ mol -1 ) G = Gibbs free energy (kJ mol -1 )Einstein vibration frequency kBoltzmann constant (1.3807 9 10 -23 J K -1 ) hPlanck constant (6.625 9 10 -34 J s) t Time (s) T Absolute temperature (K) f (a) Differential form of kinetic mechanism function g (a) Integral form of kinetic mechanism functionGreek symbols a Conversion degree b Heating rate (K min -1 )
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