Complexes of Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) with isatin N(4)-methyl(phenyl)thiosemicarbazone (ISTSC)) were synthesized in satisfactory yields. These complexes were characterized based on various physico-chemical methods. The antimicrobial activities of the metal complexes and isatin-N(4)-methyl(phenyl)thiosemicarbazone showed that the complexes are more active than the free thiosemicarbazone ligand. Moreover, in vitro cytotoxicity of all the complexes and the ligand against Dalton's Lymphona Ascites (DLA) and Ehrlich's Ascites Carcinoma (EAC) cell lines was assayed and found that they are capable of destroying the cancer cells even at low concentrations. In particular, the Cu(II) complex, [CuL]Cl.H2O exhibited higher cytotoxicity against the above cancer cell lines with an IC50 value of 38 µg/ml.
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