Anaplastic large cell lymphoma (ALCL) is a rare subtype of peripheral T cell lymphoma, which is clinically, pathologically, and genetically heterogeneous. The disease is characterized by large CD30 positive anaplastic cells that usually have horseshoe or kidney-shaped nuclei and infiltrate lymph nodes. Given the rarity of ALCL and its non-specific symptoms, it is challenging to consider a differential diagnosis at first; however, meticulous tissue biopsy and immunohistochemical staining can diagnose it. Recently, we encountered a patient who complained of facial pain, trismus and numb of lip for three months and was diagnosed with anaplastic lymphoma kinase negative ALCL of the sphenoid sinus. Here we report this rare case with review literature.
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