Background: Yeast free oligosaccharides (fOS) are cleaved from glycoproteins during ER-associated degradation of proteins (ERAD), but factors underlying their control remain to be explored. Results: Only one-half of fOS are regulated by known ERAD processes, and fOS generation and demannosylation are growth-dependent. Conclusion: Additional complexity of ERAD processes is revealed. Significance: This is the first demonstration of growth-dependent fOS regulation.
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