Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an important regulator of the cytokine storm. Hence, the evaluation of the influence of polymorphisms in key genes of the IL-6 pathway, namely IL6, IL6R, and IL6ST, may provide valuable prognostic/predictive markers for COVID-19. The present cross-sectional study genotyped three SNPs (rs1800795, rs2228145, and rs7730934) at IL6. IL6R and IL6ST genes, respectively, in 227 COVID-19 patients (132 hospitalized and 95 non-hospitalized). Genotype frequencies were compared between these groups. As a control group, published data on gene and genotype frequencies were gathered from published studies before the pandemic started. Our major results point to an association of the IL6 C allele with COVID-19 severity. Moreover, IL-6 plasmatic levels were higher among IL6 CC genotype carriers. Additionally, the frequency of symptoms was higher at IL6 CC and IL6R CC genotypes. In conclusion, the data suggest an important role of IL6 C allele and IL6R CC genotype on COVID-19 severity, in agreement with indirect evidence from the literature about the association of these genotypes with mortality rates, pneumonia, and heightening of protein plasmatic levels pro-inflammatory driven effects.
Pensado como espaço de socialização dos resultados da pesquisa científica produzida pelos professores e alunos vinculados aos programas de iniciação científica e de pós-graduação stricto sensu da UEPA, o Seminário de Integração Científica (SIC/UEPA) apresenta-se em sua oitava edição.A realização deste evento, face à participação maciça do nosso alunado envolvido em atividades de pesquisa, evidencia, antes de tudo, a responsabilidade que a UEPA tem com a formação de futuros pesquisadores. Tal formação -vale lembraré fortalecida e fomentada tanto pelo investimento que a própria UEPA faz em suas atividades de pesquisa, quanto pelas inúmeras formas de apoio que a UEPA recebe de instituições como CNPq, CAPES, FINEP e FAPESPA.Portanto, o VIII Seminário de Integração Científica reafirma o compromisso que a Universidade do Estado do Pará tem para com a missão de produzir e socializar conhecimento útil. Neste sentido, este evento procura ser uma demonstração de que produção científica qualificada dentro da UEPA é uma realidade.
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