This review will highlight the potential benefits that can be leveraged by using flow chemistry to allow a safer and more efficient way of using gases in research. An overview of the different approaches used to introduce gases into flow reactors is presented along with a synopsis of the different gaseous reactions classes already successfully translated into flow.

A novel supramolecular three-input AND logic gate is demonstrated as a 'lab-on-a-molecule' for monitoring the Na(+), pH and pE levels in solution by communicating a fluorescence signal. The fluorescence signal is modulated by three photoinduced electron transfer reactions that are controlled by an unprecedented combination of two cation binding events and one redox reaction.

Flow synthesis offers many advantages when applied to the processing of difficult or dangerous chemical transformations. Furthermore, continuous production allows for rapid scale up of reactions without significant redevelopment of the routes. Importantly, it can also provide a versatile platform from which to build integrated multi-step transformations, delivering more advanced chemical architectures. The construction of multi-purpose micro and meso flow systems, that utilize in-line purification and diagnostic capabilities, creates a scenario of seamless connectivity between sequential steps of a longer chemical sequence. In this mini perspective, we will discuss our experience of target orientated multi-step synthesis as presented at the recent inaugural meeting of LEGOMEDIC at Namar University, Belgium.

The first naphthalimide-based three-input AND logic gate detects a congregation of three cations in aqueous methanol with a 25-fold enhanced fluorescence.

SummaryA flow system to perform Chan–Lam coupling reactions of various amines and arylboronic acids has been realised employing molecular oxygen as an oxidant for the re-oxidation of the copper catalyst enabling a catalytic process. A tube-in-tube gas reactor has been used to simplify the delivery of the oxygen accelerating the optimisation phase and allowing easy access to elevated pressures. A small exemplification library of heteroaromatic products has been prepared and the process has been shown to be robust over extended reaction times.