AS may be an effective alternative to PFAT in the treatment of dry eye developed during isotretinoin use.

The present study clearly shows that the sebum content on the forehead and skin hydration of the forehead and forearm are significantly decreased in GH deficient patients with Sheehan's syndrome. However 6 months of GHRT significantly increased only the sebum content on the forehead. These data suggest that GH and/or IGF-I may have a modulatory role on several skin characteristics.

GHD results in a decrease in skin capacitance and sebum content indicating that GH and/or insulin-like growth factor-I (IGF-I) have an important role in skin function.

The effect of oral isotretinoin therapy may cause regional thinning in RNFL and macula, directly visible part of central nervous system.