SUMMARY We did this study to provide data on the elastic properties of coronary arteries, such being essential when considering the role of mechanical factors in coronary heart disease. In view of the necessity of using postmortem material to study human arteries, we made a preliminary study on the elasticity changes of a muscular artery (the femoral) after excision and cold storage. Dynamic (Ed^) and static (E*u) incremental, elastic moduli of all arteries were calculated from simultaneously recorded pressure and diameter traces, the latter, in most instances, being obtained with an existing electrical caliper. A new, light-weight, strain-gauge caliper was developed to allow direct diameter records to be obtained from the left circumflex coronary artery (LCCA) on the beating canine heart. After excision and overnight cold storage, respectively, the canine femoral artery showed increases in diameter (9.2 and 11.6%), E^,, (77 and 173%), and E
Fresh, first morning specimens of urine from 22 consecutive patients were examined by quantitative microscopy on the morning of renal biopsy; the renal biopsy samples were evaluated "blindly." Five patients showed no abnormality in the biopsy samples but eight had minimal, one mild, six moderate, and two severe histological changes. Comparison of the results of quantitative microscopy of urine with the presence or absence of histological evidence of disease showed that sensitivity was 88%, specificity 83%, accuracy 86%, positive predictive value 93%, and negative predictive value 71%.When combined with microscopy of a second urine specimen these values were 100%, 50%, 87%, 85%, and 100% respectively. There was a significant relation between number of casts and severity of the histological changes (p <0 01). Comparison of renal functional abnormalities with histological findings gave values of 64%, 100%, 73 %, 100%, and 50% respectively.
A coagulopathy associated with severe hemolysis was a limiting factor in obtaining long-term survivors among calves with total artificial hearts in 1969. Conversion of design from sac-type hearts to flexible diaphragm hearts, and from Silastic Dacron-fibril intimas to smooth polyurethane intimas, resulted in an abatement of the coagulopathy. In the most recent series of animals studied at this laboratory, platelet counts are normal and platelet survivals are half of normal. Plasma hemoglobins are normal. The coagulation system is still activated at specific loci within the total artificial heart, but is best compensated for in calves treated with antiplatelet drugs, having polyurethane hearts.
Fresh, first morning specimens of urine from 22 consecutive patients were examined by quantitative microscopy on the morning of renal biopsy; the renal biopsy samples were evaluated "blindly." Five patients showed no abnormality in the biopsy samples but eight had minimal, one mild, six moderate, and two severe histological changes. Comparison of the results of quantitative microscopy of urine with the presence or absence of histological evidence of disease showed that sensitivity was 88%, specificity 83%, accuracy 86%, positive predictive value 93%, and negative predictive value 71%.When combined with microscopy of a second urine specimen these values were 100%, 50%, 87%, 85%, and 100% respectively. There was a significant relation between number of casts and severity of the histological changes (p <0 01). Comparison of renal functional abnormalities with histological findings gave values of 64%, 100%, 73 %, 100%, and 50% respectively.
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