Background Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of neonatal sepsis. In the BARNARDS observational cohort study of neonatal sepsis and antimicrobial resistance in LMICs, common sepsis pathogens were characterised via whole genome sequencing (WGS) and antimicrobial resistance profiles. In this substudy of BARNARDS, we aimed to assess the use and efficacy of empirical antibiotic therapies commonly used in LMICs for neonatal sepsis.Methods In BARNARDS, consenting mother-neonates aged 0-60 days dyads were enrolled on delivery or neonatal presentation with suspected sepsis at 12 BARNARDS clinical sites in

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The use of dentures is becoming common even among Africans. So also is the problem of swallowed and impacted dentures. Their radiolucence makes radiological localization almost impossible, and because of their rigidity, large size, irregular and unyielding edges, impacted dentures are apt to produce lacerations during endoscopic removal from gullets rendered friable by impaction. Three patients with impacted radiolucent dentures are described in order to illustrate the problems of removal. It is suggested that the safest most effective method of removing impacted dentures in the esophagus is through an elective open esophagotomy.

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