The present work has as main objective to investigate the use of fractional calculus in the modeling of epidemic outbreaks of interacting populations. In particular, we propose a generalization of the SIR model with fractional derivatives to describe the dynamics of the COVID-19 epidemic outbreak in two cities with interacting populations. In special, we consider the dynamics of COVID-19 in the municipalities of Pelotas and Rio Grande, which are neighboring cities and are relatively geographically isolated from the rest of the state of Rio Grande do Sul.
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