Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Heritability and polygenic predictionIn the EUR sample, the SNP-based heritability (h 2 SNP ) (that is, the proportion of variance in liability attributable to all measured SNPs)

No abstract

Background: Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease, are calculated as a weighted count of risk alleles identified in genome-wide association studies (GWASs). PGS methods differ in which DNA variants are included and the weights assigned

Several groups have reported weak evidence for linkage between schizophrenia and genetic markers located on chromosome 22q using the lod score method of analysis. However these findings involved different genetic markers and methods of analysis, and so were not directly comparable. To resolve this issue we have performed a combined analysis of genotypic data from the marker D22S278 in multiply affected schizophrenic families derived from 11 independent research groups worldwide. This marker was chosen because it showed maximum evidence for linkage in three independent datasets (Vallada et al., Am J Med Genet 60:139‐146, 1995; Polymeropoulos et al., Neuropsychiatr Genet 54:93‐99, 1994; Lasseter et al., Am J Med Genet, 60:172‐173, 1995). Using the affected sib‐pair method as implemented by the program ESPA, the combined dataset showed 252 alleles shared compared with 188 alleles not shared (chi‐square 9.31, 1df, P = 0.001) where parental genotype data was completely known. When sib‐pairs for whom parental data was assigned according to probability were included the number of alleles shared was 514.1 compared with 437.8 not shared (chi‐square 6.12, 1df, P = 0.006). Similar results were obtained when a likelihood ratio method for sib‐pair analysis was used. These results indicate that there may be a susceptibility locus for schizophrenia at 22q12. © 1996 Wiley‐Liss, Inc.