Gastrointestinal cancers continue to account for a disproportionately large percentage of annual cancer deaths in the United States. Advancements in miniature imaging technology combined with a need for precise and thorough tumor detection in gastrointestinal cancer screenings fuel the demand for new, small-scale, and low-cost methods of localization and margin identification with improved accuracy. Here, we report the development of a miniaturized, chip-on-tip, multispectral, fluorescence imaging probe designed for compatibility with a gastroscope working channel with the aim of detecting cancerous lesions in point-of-care endoscopy of the gastrointestinal lumen. Preclinical testing has confirmed fluorescence sensitivity and supports that this miniature probe can locate structures of interest via detection of fluorescence emission from exogenous contrast agents. This work demonstrates the design and preliminary performance evaluation of a miniaturized, single-use, chip-on-tip fluorescence imaging system, capable of detecting multiplexed fluorophores, and devised for deployment via the accessory channel of a standard gastroscope.
As gastrointestinal cancers continue to cause a disproportionately large percentage of annual cancer deaths in the US, advancements in miniature imaging technology combined with a need for precise and thorough tumor detection in gastrointestinal cancer screenings fuel the demand for new, small-scale, and low-cost methods of localization and margin detection with improved accuracy. A miniaturized, chip-on-tip, multispectral, fluorescence imaging probe designed to port through a gastroscope working channel has been developed for detection of cancerous lesions in the gut lumen in point of care gastrointestinal endoscopy. Preclinical testing has confirmed fluorescence sensitivity and supports that this miniature probe can locate structures of interest via detection of fluorescence emission from exogenous contrast agents. This work demonstrates the design and preliminary performance evaluation of a miniaturized, single-use, chip-on-tip fluorescence imaging system devised for deployment via the accessory channel of a standard gastroscope.
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