Background: Nowadays, existence of self-motivated and efficient human resource is a key issue of great importance in the telecommunication industry. Considering that human resource in an organization is significant resources, steps should be taken to find the strong and weak points in enhancing the operation of increasing efficiency in the firm. Moreover, job satisfaction has been considered one of the important factors in the provision of superior performance and high quality services at the telecommunication industry. Problem: Considering the telecommunication industry that is one of the primary industries in the poor performing sector of Cameroon. An industry is growing at high speed by adopting unfair practices. Operators are not satisfied with the current government regulations towards issuance of SIM's and the imposition of XAF 3.5 billion fine. Purpose: This study aimed to explore the impacts of job stress (JS), work environment (WE), overall compensation benefits and pay (OCS), leadership, and moderating role of leadership on employees' job satisfaction (EJS). Method: A quantitative method was employed in the sample size of 515 responses. A technique of random sampling was used to select the respondents. Data was collected through a field survey by using a closed-ended questionnaire. The analysis was done through SmartPLS 3.0. Results: The results have supported the hypothesized model. Indeed, findings proved a significant relationship between JS, WE, OCS, leadership, and EJS. Leadership significantly moderates the relationship between JS, WE, OCS, and EJS.