Surgical site infections are the most common hospital acquired infection in both developed and developing countries. In the period from June 2019 to May 2020, 300 patients admitted for surgery were assessed preoperatively, intraoperatively and postoperatively Out of 300 samples collected from post operative cases with symptomatic wound infection, 157(52.3%) samples showed positive culture. Out of 157 isolates 128(81.5%) isolates are gram negative organisms and 26(18.4%) isolates are gram positive organism, among gram negative isolates Klebsiella pneumoniae (32.48%) is the predominant pathogen. In the present study found that Imipenem, Meropenem, Aztreonam, Piperacillin-Tazobectam were the most effective drugs for gram negative bacteria and Linezolid, Vancomycin and Teicoplanin were the most sensitive drugs for gram positive bacteria.
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