PICO question In transfusion-naïve cats receiving a type specific blood transfusion is cross-matched blood (major and minor) associated with an increased haematocrit development and reduction in acute transfusion reactions when compared with those receiving non-crossmatched blood? Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Ten papers were critically reviewed. There were four retrospective case series, three prospective cross-sectional surveys, a retrospective cohort study, a prospective case series and a prospective randomised control trial. Strength of evidence Weak Outcomes reported It would appear that in the United Kingdom the incidence of non-AB transfusion reactions is low. A single study suggests that cross-matching may result in a greater improvement in haematocrit, but this is unlikely to be clinically significant. There is evidence to support the hypothesis that non-AB antigens (for example the Mik antigen) differ with geographic distribution. Conclusion Based on the information available it is it is challenging to establish a meaningful clinical conclusion on which to base a recommendation. How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Background: Blood transfusions have been performed by vets for decades and are increasingly being performed in feline practice; they allow us to treat conditions that would not be possible without this option.Aim of the article: This article discusses findings from recent research that impact on performing transfusion in cats and highlights controversies that should be taken into account when considering blood transfusion.
To assess the utility of urea and blood urea nitrate:creatinine ratio (UCR) to predict gastrointestinal bleeding (GIB) in dogs presenting at referral centres for evaluation of anaemia. MethodsRetrospective crosssectional study of client owned dogs presenting to 8 referral centres in the United Kingdom for investigation of anaemia between November 2017 and July 2018. Dogs were classified as GIB confirmed (n=28) or ruled out (n=37) based on clinical examination and diagnostic testing. Cases where gastrointestinal bleeding was not confirmed or ruled out, were excluded from analysis. A logistic regression algorithm was applied to the data and then classification performance in terms of sensitivity and specificity were reported in a receiver operating characteristic (ROC) curve. Median plasma urea and UCR were compared using a Mann-Whitney U test. Demographic and baseline characteristics were compared between the two groups using a Mann-Whitney U test for quantitative parameters and a Chisquared test for qualitative parameters.
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